AI-based models for the identification of critical genetic biomarkers to distinguish MM from MGUS using the WES data
Published in Clinical Lymphoma Myeloma and Leukemia, 2021
MGUS and MM share many common features such as genomic biomarkers, structural variants etc. with the difference of having less impact of mutations in MGUS. Thus, it is challenging to distinguish MM from MGUS. Here, we utilized ML classifi ers to distinguish MM from MGUS. Our classifi ers are able to identify the signifi cant genes that are helpful in MM vs. MGUS classifi cation that can lead to a better understanding of progression from MGUS to MM.
Recommended citation: Ruhela, V., Farswan, A., Gupta, A., Kaur, G. and Gupta, R., 2021. P-035: AI-based models for the identification of critical genetic biomarkers to distinguish MM from MGUS using the WES data. Clinical Lymphoma Myeloma and Leukemia, 21, p.S57. https://doi.org/10.1016/S2152-2650(21)02169-8
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